There are currently two schools of thought in the transhumanist community:
One, which you’ve mentioned, revolves around the idea of overcoming the limits of DNA. Research into various creatures, including (but not limited to) the jellyfish fall into this camp.
Their general goal seems to be that we should work to reverse our aging process, then create a mechanism by which cells are constantly repaired perfectly, and the used garbage cells are flushed out…preferably without causing cancer when they do.
The second school of thought, the one which I belong to, takes a different approach. Our idea is that life extension could be achieved through technological innovation revolving around shedding the body entirely.
Instead of concerning ourselves with keeping the entire body alive, we should focus on the development of nanotechnology for the purpose of keeping the brain alive indefinitely.
With the ability to build new, custom bodies that we merely move the immortal brains into, any catastrophic accident would become more of a nuisance than anything else.
Additionally, being able to build custom bodies resolves numerous issues with old bodies that a simple age reversal would not address:
What if we wanted to be taller, shorter, a different color, race, face, or gender? Suppose we want to alter our eye color? These last two can be done with present technology, but a male to female operation does not provide the ability to become pregnant, and altering a persons eye color comes with the serious danger of the permanent loss of sight.
Certainly, a face can be altered through plastic surgery, but that wouldn’t improve your singing voice, nor would it increase your tolerance to pain.
The custom body solution is one which resolves all these issues, while also providing opportunities for augmented physical performance like speed and strength.
When you eliminate issues such as mobility and the ability to grasp objects, the rest of the body is little more than a life support system for itself and the brain.
Scrapping and replacing the body? That makes sense. Like getting a new car when the old one wears out.
To get from here to there, however, isn’t a straight line. Long before we learn to build a custom body which can serve as a life support system for the brain, we will need to first learn to build a life support system for the brain.
This means some people, and preferably, a good cross section of them, will need to take the plunge. To agree to live in a virtual environment while humanity (and an artificially intelligent computer) works to sort out how to improve on the initial technology to create the kind of artificial custom bodies desired.
On the plus side, there are things to do while an AI works towards that goal. One way to get a bigger bang for the buck would be to combine fusion energy (which Europe is very close to perfecting) with something akin to the emDrive/Cannae drive (a propulsion unit that goes by two different names, depending on who you ask.)
With these minds on a craft headed for one of the possible planets which may be able to support life (yet are approximately a thousand light years away) traveling at near light speed using these drives would give the potential colonists time to discuss and perfect a viable political system to organize their new colony around.
In all likelihood, such a new government would combine the best ideas ever created or tried in the entire history of humanity…coupled with a thousand years of discussion and testing by people with IQ’s thousands of times smarter than we are today, using the input of a machine billions of times smarter than any human who has ever lived.
The result may not be perfect, but it would doubtless be a damn site better than anything yet tried.